When evaluating mg patients: When evaluating mg patients



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tarix28.01.2017
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When evaluating MG patients:





Definition of Improved, Unchanged, Worsened is still a gray area:

  • Definition of Improved, Unchanged, Worsened is still a gray area:

  • Outcome may depend on how it is evaluated

  • Clinically relevant changes need to be defined

  • Is the minimal change of a specific score meaningful to truly describe patients’ improvement? (PROM)

  • Need of further comparative studies



524 visits from 131 MG patients were compared on different scoring systems, Physician, INCB-MG, MGFA-PIS, QMG, MG-C, MG-ADL

  • 524 visits from 131 MG patients were compared on different scoring systems, Physician, INCB-MG, MGFA-PIS, QMG, MG-C, MG-ADL

  • Weighted Cohen K coefficient was used:

  • 0 = no concordance, 1= complete concordance

  • Values are given as 1-k: the higher 1-k value, the higher the discordance









Outcomes measures in MG should reflect the intrinsic features of the disease

  • Outcomes measures in MG should reflect the intrinsic features of the disease

  • Be useful both for clinical practice and experimental settings

  • Have a good concordance between patients and physicians

  • Need of further studies aimed at homogeneity, relevant for international studies







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