Vital Annex: International Journal of Novel Research in Advanced Sciences (ijnras)

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Vital Annex: International Journal of Novel Research in Advanced Sciences 
(IJNRAS) 
Volume: 01 Issue: 05 | 2022 ISSN: 2751-756X  
http://innosci.org 
 
396 | Page 
Reasons for the Development of Morphostructural Changes in Kidney Cells in 
Patients with Rheumatoid Arthritis 
 
Mustafayeva Shargiya Akhmadovna 
Assistant of the Department of Rehabilitology, Sports Medicine and Physical Education of the 
Bukhara State Medical Institute named after Abu Ali ibn Sino 
 
Annotation:
The scientific review is intended for one of the urgent problems of modern 
medicine - kidney damage in rheumatoid arthritis. The issues of prevalence and risk factors of 
chronic kidney disease are considered. The kidneys are affected in rheumatoid arthritis more often 
than it is diagnosed. As a result, early diagnosis of kidney damage in patients with rheumatoid 
arthritis has an important clinical and prognostic value. In rheumatoid arthritis, the occurrence of 
chronic kidney disease depends primarily on the duration of the disease and the nature of the 
inflammatory process. A higher incidence of RA among first-degree relatives of patients was 
established than in the general population. These data are fully confirmed at the present time. The 
problem of kidney damage in rheumatoid arthritis is poorly understood and requires further 
research. 
Keywords:
rheumatoid arthritis, chronic kidney disease, glomerulonephritis, amyloidosis. 
 
 
Rheumatic diseases are the oldest human pathology, and are considered the most common ailments 
of the XXI century. In recent decades, there has been some progress in the field of theoretical and 
clinical rheumatology. According to E.A. Galushko and E.L. Nasonov's rheumatic diseases include 
more than 80 diseases and syndromes [31]. Rheumatoid arthritis (RA) is an autoimmune disease 
characterized by the development of chronic destructive polyarthritis with frequent involvement in 
tological process of other systems. Extra-articular systemic lesions in RA can have a serious impact 
on the prognosis of the disease [8, 39]. 
Large studies conducted in recent years have demonstrated the association of RA with a high risk of 
chronic kidney disease (CKD) and cardiovascular complications, which is associated with an 
increase in mortality in this category of patients [9, 27,18]. The spectrum of renal pathology 
underlying CKD in RA is quite wide. Secondary amyloidosis for many years occupied the main 
position among the variants of nephropathy in patients with RA [23,44]. According to some studies, 
there is a tendency to change the structure of kidney damage in RA [5], given the use of highly 
effective therapy regimens, including genetically engineered drugs, which is an additional 
prerequisite for studying this category of patients. 
Earlier in the works of V.A. Nasonova noted that women everywhere suffer from RA more often 
than men (4:1). Moreover, in women, the incidence of RA increases with age [40].
In addition, 
a higher incidence of RA was found among first-degree relatives of patients than in the general 
population. These data are fully confirmed at present [3]. The formation of nephropathy in RA is 
multifactorial, which is represented by the variety of their clinical and morphological variants with 
minor, nonspecific changes in urine tests. 
The course of rheumatoid nephropathy, as well as other chronic kidney diseases, is progressive in 
nature with the development of nephrosclerosis and a decrease in the foothold of functioning 

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