Unlike Dick the Butcher

Low Evidence

• Insufficient to assess effects on health outcomes because of limited number or power of studies, large and unexplained inconsistency between higher-quality studies; important flaws in design or conduct, gaps in the chain of evidence
• Or lack of information on important health outcomes

Strength of recommendation

• Strength of recommendation

• Strong:

• Benefits clearly > risks and burden OR risks and burden clearly > benefits

• Weak:

• Benefits finely balanced with risks and burden

• Insufficient:

• Insufficient evidence to determine net benefits or risks

• Continuous arrivals of new drugs on the market1

• Older formulations unavailable in European formularies2

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