Description

Extracorporeal Dialysis 
Follow equipment manufacturers’ operating directions carefully. 
Blood Transfusion 
Addition of 400 to 600 USP units per 100 mL of whole blood is usually employed to prevent 
coagulation. Usually, 7500 USP units of heparin sodium are added to 100 mL of 0.9
% Sodium 
Chloride Injection, USP (or 75,000 USP units per 1000 mL of 0.9
% Sodium Chloride Injection, USP) 
and mixed; from this sterile solution, 6 to 8 mL are added per 100 mL of whole blood. 
Laboratory Samples 
Addition of 70 to 150 units of heparin sodium per 10 to 20 mL sample of whole blood is usually 
employed to prevent coagulation of the sample. Leukocyte counts should be performed on heparinized 
blood within 2 hours after addition of the heparin. Heparinized blood should not be used for 
isoagglutinin, complement, or erythrocyte fragility tests or platelet counts. 
HOW SUPPLIED 
Heparin Sodium Injection, USP 
1000 USP units/mL 
1 mL DOSETTE vial packaged in 25s (NDC 0641-0391-25) 
10 mL Multiple Dose vial packaged in 25s (NDC 0641-2440-45) 
30 mL Multiple Dose vial packaged in 25s (NDC 0641-2450-45) 
5000 USP units/mL 
1 mL DOSETTE vial packaged in 25s (NDC 0641-0400-25) 
10 mL Multiple Dose vial packaged in 25s (NDC 0641-2460-45) 
10,000 USP units/mL 
1 mL DOSETTE vial packaged in 25s (NDC 0641-0410-25) 

---

NDA 17-037/S-158 
Page 12 
4 mL Multiple Dose vial packaged in 25s (NDC 0641-2470-45) 
Also available from Baxter: HEP-LOCK (Heparin Lock Flush Solution, USP) and HEP-LOCK U/P 
(Preservative-Free Heparin Lock Flush Solution, USP). 
Storage 
Store at 20
°-25°C (68°-77°F) [see USP Controlled Room Temperature]. 
Baxter, Hep-Lock and Dosette are trademarks of Baxter International, Inc., or its subsidiaries. 
REFERENCES: 
1. 
Tahata T, Shigehito M, Kusuhara K, Ueda Y, et al. Delayed-Onset of Heparin
Induced 
Thrombocytopenia – A Case Report – J Jpn Assn Torca Surg.
1992;40(3):110-111. 
2. 
Warkentin T, Kelton J. Delayed-Onset Heparin-Induced Thrombocytopenia and Thrombosis. 
Annals of Internal Medicine. 2001;135:502-506. 
3. 
Rice L, Attisha W, Drexler A, Francis J. Delayed-Onset Heparin Induced Thrombocytopenia. 
Annals of Internal Medicine, 2002;136:210-215. 
4. 
Dieck, J., C. Rizo-Patron, et al. (1990). “A New Manifestation and Treatment
Alternative 
for Heparin-Induced Thrombosis.”. Chest 98(1524-26). 
5. 
Smythe M, Stephens J, Mattson. Delayed-Onset Heparin Induced Thrombocytopenia. 
Annals of Emergency Medicine, 2005;45(4):417-419 
6. D
IVGI 
A.
(R
EPRINT
),
T
HUMMA 
S.,
H
ARI 
P.,
F
RIEDMAN 
K.,
D
ELAYED 
O
NSET 
H
EPARIN
- I
NDUCED 
T
HROMBOCYTOPENIA 
(HIT)
P
RESENTING 
A
FTER 
U
NDOCUMENTED 
D
RUG 
E
XPOSURE AS 
P
OST
-
A
NGIOGRAPHY 
P
ULMONARY EMBOLISM
.B
LOOD
.2003;102(11):127
B
. 
Manufactured by