.The stomach secretes gastric juice every day. Gastric juice consists of digestive enzymes and concentrated hydrochloric acid, which can tear apart the toughest food and microorganism.It used to be thought that the stomach contained no bacteria and was actually sterile, but H. pylori changed that view.
Why and how does HP cause diseases?
Let’s talk about HP in this lecture?
General description of H.pylori
Biological characteristics of H.pylori
Defense mechanism of H.pylori
Detection and treatment
General description of H. pylori
1.H. pylori is a newly discovered stomach infection which was first reported by Barry Marshall and Robin Warren of Perth, Western Australia, in 1983.
2. The bacterium lives in the stomach of about half the people in the world. Many are apparently well, and most have an inflammation of the stomach lining, a condition which is called "gastritis".
3. Gastritis is the underlying condition which causes ulcers and other digestive complaints, possibly including cancer of the stomach.
Once H. pylori is ensconced in the mucus, it is able to fight the stomach acid that does reach it with an enzyme called urease.
Urease converts urea, of which there is an abundant supply in the stomach (from saliva and gastric juices), into bicarbonate and ammonia, which are strong bases. This creates a cloud of acid neutralizing chemicals around the H. pylori, protecting it from the acid in the stomach.
The reaction of urea hydrolysis is important for diagnosis of H.pylori by the breath test.