Microsoft Word search phase 3 Title Page Amendment

STUDY OBJECTIVES & BACKGROUND AND SIGNIFICANCE .............................. 1
 
4.1. 
SEARCH
 
REGISTRY
 
STUDY
 
OBJECTIVES ............................................................  1 
4.1.1.
 
Goals ......................................................................................................................... 1
 
4.2. 
BACKGROUND
 
AND
 
SIGNIFICANCE .................................................................... 3 
4.2.1.
 
Importance of Diabetes Registries in Youth ............................................................. 3
 
4.2.1.1.  Overview, Strengths and Limitations .................................................................... 3 
4.2.2.
 
Burden of Diabetes, Disparities, Clinical Presentation, Patterns of Care, Quality of 
Care ................................................................................................................................... 4
 
4.2.2.1.  Burden of Diabetes in Youth ................................................................................. 4 
4.2.2.2.  Health Disparities .................................................................................................. 4 
4.2.2.3.  Clinical Presentation and Patterns of Care ............................................................ 5 
4.2.2.4.  Quality of Life (QOL) ........................................................................................... 5 
4.2.3.
 
Temporal Trends in the Incidence of Childhood Diabetes ....................................... 6
 
4.2.3.1.  Type 1 Diabetes ..................................................................................................... 6 
4.2.3.2.  Trends in Genetic Susceptibility to T1D ............................................................... 7 
4.2.3.3.  Trends in Clinical Presentation ............................................................................. 8 
4.2.4.
 
Type 2 Diabetes....................................................................................................... 10
 
4.3. 
PUBLIC
 
HEALTH
 
SURVEILLANCE
 
OF
 
DIABETES
 
IN
 
YOUTH ........................ 11 
4.3.1.
 
Rationale .................................................................................................................  11
 
4.3.2.
 
Limitations of Existing Systems and Role of SEARCH ........................................... 12
 
4.4. 
MORTALITY
 
IN
 
YOUTH
 
WITH
 
DIABETES ......................................................... 12 
R
EFERENCE 
L
IST
 .........................................................................................................................  14 
 
 

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Section 4A - Study Objectives/Background and Significance (Phase 3 - 11/2010) 
Section 4A - Page 1 
 Registry 
Study